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Thrombus FP7 European Project
Objectives[modifier | modifier le code]
Rupture risk of intracranial aneurysms (IA) has been studied at length. However, very little is known about the healing mechanism, namely the formation of a clot inside the cavity after insertion of a stent. The multiscale interaction between biological and hemodynamic processes is the central ingredient of this proposal. The core of the project is to develop and validate a biological model of spontaneous or stent-induced thrombosis in IA. From this model we will compute quantitative stent efficiency score by its capability to induce clotting in aneurysms. In medical practice the choice of which stent to deploy is left to the medical doctor and remains intuitive to date. It is common to use one or several full-course stents into each other, in order to induce thrombosis formation. Recent Pipeline stents allowing simple or multiple devices constructs with variable flow disruption will be investigated. Our project will study through numerical simulation the effect of stent configuration in patient specific geometry and will help explain why some stents produce good thrombus while others don't.
The project will develop a multi-scale computational modelling and simulation framework based on the triptych In Vitro - In Vivo - In Silico - rule of three for the thrombosis. The associated technological aim of the project is to deliver software with an interactive end-user interface, providing a virtual simulation of the thrombosis leading to the optimal stent for a specific patient s aneurysm. This goal will be achieved by integrating some of the leading open source software and VPH toolkit software in the area of computational bioengineering. Also a collaborative online system will be adapted allowing partners of THROMBUS to correlate any type of data in case simultaneous multidisciplinary analysis by distant partners is required. This platform will remain operational after the end of the project.
Thrombus has the potential to challenge the practices of medical doctors and stents manufacturers (Market ~ $1.1 billion in 2012). The main target group is those of the patients; the introduction of endovascular prostheses that limit flow from entering the aneurysm cavity has yielded promising results but some progresses in the diagnosis are requested in order to confirm that this is the best treatment to apply for a patient specific.
Target groups:
Patients Neuroradiologists Neurosurgeons Stent manufacturers
Coordinator: Guy Courbebaisse - http://www.creatis.insa-lyon.fr/~courbebaisse
Consortium[modifier | modifier le code]
9 EUROPEAN PARTNERS:
-1- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - INSA LYON - FRANCE
-2- ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE - SWITZERLAND
-3- HOSPICES CIVILS DE LYON - HOPITAL DE NEURORADIOLOGIE - FRANCE
-4- UNIVERSITEIT VAN AMSTERDAM - NEDERLAND
-5- UNIVERSITE LIBRE DE BRUXELLES - CHU CHARLEROI - BELGIQUE
-6- UNIVERSITY of SIEGEN - DEUTSCHLAND
-7- UNIVERSITE DE GENEVE - SWITZERLAND
-8- COVALIA INTERACTIVE SA - FRANCE
-9- ev3 EUROPE SAS - FRANCE
International collaborations[modifier | modifier le code]
- University of TOHOKU - Institute of Fluid Science - http://www.ifs.tohoku.ac.jp/divisions/en/ifsd_bcl.html
- Harvard Medical School - Guillermo Cardenas Lab.: http://garcia-cardena.bwh.harvard.edu
- Pontificia Universidad Javeriana - Facultad de Ingeniería - Departamento Ingeniería de Sistemas : http://puj-portal.javeriana.edu.co/portal/page/portal/Facultad%20de%20Ingenieria/dpto_sist_presentacion
See also[modifier | modifier le code]
- ESMINT : http://www.esmint.eu/
- EANS : http://www.eans.org/pages/home/
- SFNR : http://www.sfnr.net/
- Thrombus : https://fr.wikipedia.org/wiki/Thrombus
- Aneurysm : https://en.wikipedia.org/wiki/Aneurysm
Reference[modifier | modifier le code]
Collaborative Project FP7 - ICT - 2009.5.3 n°269966 - [ February 2012 - April 2014 ]
External links[modifier | modifier le code]
- Thrombus Project : http://www.thrombus-vph.eu
- Cordis FP7 ICT Thrombus : http://cordis.europa.eu/projects/rcn/97461_en.html
- Cordis FP7 Health Thrombus : http://www.healthcompetence.eu/converis/publicweb/project/3194?show=Person
- Virtual Physiological Human : http://en.wikipedia.org/wiki/Virtual_Physiological_Human
- Cordis FP7 VPH NOE Project : http://www.vph-noe.eu/
- ePractice.eu : http://www.epractice.eu/en/cases/thrombus