TGF bêta 2

TGFB2
	Structure de la protéine TGFB2. Basé sur l'identifiant PDB 1TFG.
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1TFG, 2TGI, 4KXZ
Identifiants
Aliases	TGFB2, Transforming growth factor-beta 2
IDs externes	OMIM: 190220 MGI: 98726 HomoloGene: 2432 GeneCards: TGFB2
Position du gène (Homme)
Chr.	Chromosome 1 humain
Fin	218,444,619 bp
Position du gène (Souris)
Chr.	Chromosome 1 (souris)
Fin	186,438,186 bp
Expression génétique
	Fortement exprimé dans
	tendon calcanéen; ; germinal epithelium; ; sperme; ; Glandes accessoires; ; tibia; ; îlot de Langerhans; ; muscle lisse; ; artère coronaire droite; ; endocol; ; follicule pileux;
	Fortement exprimé dans
	corps ciliaire; ; iris; ; artère carotide externe; ; secondary oocyte; ; artère carotide interne; ; valve sigmoïde; ; glande submandibulaire; ; atrioventricular canal; ; glande pinéale; ; aorte ascendante;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	type II transforming growth factor beta receptor binding; signaling receptor binding; type III transforming growth factor beta receptor binding; cytokine activity; transforming growth factor beta receptor binding; growth factor activity; protein homodimerization activity; amyloid-beta binding; liaison protéique; protein heterodimerization activity;
Composant cellulaire	région extracellulaire; matrice extracellulaire; platelet alpha granule lumen; milieu extracellulaire; axone; neuronal cell body; collagen-containing extracellular matrix;
Processus biologique	développement de l'œil; regulation of transforming growth factor beta2 production; response to progesterone; mort cellulaire; cardioblast differentiation; positive regulation of integrin biosynthetic process; phosphorylation des protéines; positive regulation of heart contraction; positive regulation of neuron apoptotic process; angiogenèse; negative regulation of epithelial cell proliferation; uterine wall breakdown; negative regulation of alkaline phosphatase activity; negative regulation of macrophage cytokine production; positive regulation of cell adhesion mediated by integrin; prolifération cellulaire; transforming growth factor beta receptor signaling pathway; negative regulation of cell population proliferation; positive regulation of stress-activated MAPK cascade; cell-cell junction organization; extrinsic apoptotic signaling pathway; collagen fibril organization; positive regulation of epithelial cell migration; neutrophil chemotaxis; positive regulation of cell growth; response to wounding; negative regulation of cell growth; positive regulation of cardioblast differentiation; glial cell migration; cicatrisation; positive regulation of ossification; cardiac muscle cell proliferation; positive regulation of epithelial to mesenchymal transition; odontogenèse; positive regulation of timing of catagen; positive regulation of immune response; regulation of complement-dependent cytotoxicity; positive regulation of protein secretion; Transition épithélio-mésenchymateuse; embryonic digestive tract development; response to hypoxia; cell-cell signaling; positive regulation of pathway-restricted SMAD protein phosphorylation; heart morphogenesis; platelet degranulation; salivary gland morphogenesis; génération des neurones; negative regulation of immune response; cell morphogenesis; positive regulation of cell population proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; migration cellulaire; activation of protein kinase activity; positive regulation of cell division; cardiac epithelial to mesenchymal transition; BMP signaling pathway; développement d'une cellule; skeletal system development; kidney development; neural tube closure; hair follicle development; outflow tract septum morphogenesis; membranous septum morphogenesis; heart valve morphogenesis; atrioventricular valve morphogenesis; pulmonary valve morphogenesis; endocardial cushion morphogenesis; cardiac right ventricle morphogenesis; ventricular trabecula myocardium morphogenesis; endocardial cushion fusion; atrial septum primum morphogenesis; neural retina development; développement du cœur; male gonad development; hématopoïèse; embryonic limb morphogenesis; hair follicle morphogenesis; ascending aorta morphogenesis; dopamine biosynthetic process; positive regulation of cell cycle; negative regulation of Ras protein signal transduction; division d'une cellule souche somatique; développement d'un neurone; inner ear development; uterus development; pathway-restricted SMAD protein phosphorylation; ventricular septum morphogenesis; atrial septum morphogenesis; pharyngeal arch artery morphogenesis; regulation of apoptotic process involved in outflow tract morphogenesis; substantia propria of cornea development; cranial skeletal system development; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; regulation of signaling receptor activity; negative regulation of gene expression; negative regulation of angiogenesis; positive regulation of Notch signaling pathway; SMAD protein signal transduction; positive regulation of pri-miRNA transcription by RNA polymerase II; embryo development ending in birth or egg hatching; regulation of timing of catagen; secondary palate development; regulation of cell population proliferation; regulation of apoptotic process; regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologues
	7042
	21808
	ENSG00000092969
	ENSMUSG00000039239
	P61812
	P27090
	NM_003238; NM_001135599
	NM_009367; NM_001329107
	NP_001129071; NP_003229
	NP_001316036; NP_033393
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le TGFB2 (pour « Transforming growth factor-beta 2 ») en français facteur de croissance transformant 2 est une protéine dont le gène est le TGFB2 situé sur le chromosome 1 humain. Il s'agit de l'un des sous-types des TGF-β.

Rôle[modifier | modifier le code]

Il intervient dans la voie de signalisation des Smad.

En médecine[modifier | modifier le code]

Une mutation de son gène entraîne un anévrisme aortique thoracique dans le cadre d'un syndrome de Loeys-Dietz^[5].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000092969 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000039239 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ (en) Lindsay ME, Schepers D, Bolar NA et al. « Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm » Nat Genet, 2012;44:922–927.

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000092969 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000039239 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Lindsay_2012-5] (en) Lindsay ME, Schepers D, Bolar NA et al. « Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm » Nat Genet, 2012;44:922–927.

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