BCL2L2

BCL2L2
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM
Identifiants
Aliases	BCL2L2
IDs externes	OMIM: 601931 MGI: 108052 HomoloGene: 2989 GeneCards: BCL2L2
Position du gène (Homme)
Chr.	Chromosome 14 humain
Fin	23,311,751 bp
Position du gène (Souris)
Chr.	Chromosome 14 (souris)
Fin	55,125,691 bp
Expression génétique
	Fortement exprimé dans
	C1 segment; ; cortex préfrontal; ; amygdale; ; right frontal lobe; ; gyrus postcentral; ; lateral nuclear group of thalamus; ; Brodmann area 9; ; cortex orbitofrontal; ; gyrus cingulaire; ; muscle layer of sigmoid colon;
	Fortement exprimé dans
	medial dorsal nucleus; ; lobe of cerebellum; ; habenula; ; Subiculum; ; Vermis du cervelet; ; medial geniculate nucleus; ; pontine nuclei; ; Aire tegmentale ventrale; ; noyau vestibulaire médian; ; Corps géniculé latéral;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; protein homodimerization activity; disordered domain specific binding; identical protein binding; protein heterodimerization activity; BH domain binding;
Composant cellulaire	cytoplasme; cytosol; mitochondrial membranes; mitochondrie; membrane; membrane mitochondrial externe; Bcl-2 family protein complex; noyau; nuclear inclusion body;
Processus biologique	spermatogenèse; regulation of apoptotic process; negative regulation of apoptotic process; Sertoli cell proliferation; apoptose; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; cellular response to estradiol stimulus; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologues
	599
	12050
	ENSG00000129473
	ENSMUSG00000089682
	Q92843
	P70345
	NM_004050; NM_001199839
	NM_007537
	NP_001186768; NP_004041
	NP_031563
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le BCL2L2, ou BCL-W est une protéine appartenant à la famille Bcl-2. Son gène est le BCL2L2 situé sur le chromosome 14 humain.

Rôles

Il est exprimé dans plusieurs tissus : cerveau, côlon, testicules (intervenant dans la spermatogenèse^[5]), cellules sanguines^[6]...

Il joue un rôle protecteur sur les cellules lymphoïdes et myéloïdes^[7].

Son expression est diminué par le microARN 15a^[8] et est régulé par le MYC^[9].

En médecine

Il est exprimé dans plusieurs types de cancers : cancer de l'estomac^[10], du côlon^[11], plusieurs lymphomes (dont c'est un marqueur de mauvais pronostic^[9])... favorisant l'extension de ces derniers par son activité anti-apoptose.

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000129473 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000089682 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Print CG, Loveland KL, Gibson L et al. Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant, Proc Natl Acad Sci USA, 1998;95:12424–12431
↑ O’Reilly LA, Print C, Hausmann G, Moriishi K, Cory S, Huang DC, Strasser A, Tissue expression and subcellular localization of the pro-survival molecule Bcl-w, Cell Death Differ, 2001;8:486–494
↑ Gibson L, Holmgreen SP, Huang DC et al. bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene, 1996;13:665–675
↑ Yang T, Thakur A, Chen T et al. MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer, Tumour Biol, 2015;36:4357–4365
↑ ^{a et b} Adams CM, Kim AS, Mitra R, Choi JK, Gong JZ, Eischen CM, BCL-W has a fundamental role in B cell survival and lymphomagenesis, J Clin Invest, 2017;127:635-650
↑ Lee HW, Lee SS, Lee SJ, Um HD, Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation, Cancer Res, 2003;63:1093–1100
↑ Wilson JW, Nostro MC, Balzi M, Faraoni P, Cianchi F, Becciolini A, Potten CS, Bcl-w expression in colorectal adenocarcinoma, Br J Cancer, 2000;82:178–185

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000129473 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000089682 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Print_1998-5] Print CG, Loveland KL, Gibson L et al. Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant, Proc Natl Acad Sci USA, 1998;95:12424–12431

[O’Reilly_2001-6] O’Reilly LA, Print C, Hausmann G, Moriishi K, Cory S, Huang DC, Strasser A, Tissue expression and subcellular localization of the pro-survival molecule Bcl-w, Cell Death Differ, 2001;8:486–494

[Gibson_1996-7] Gibson L, Holmgreen SP, Huang DC et al. bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene, 1996;13:665–675

[Yang_2015-8] Yang T, Thakur A, Chen T et al. MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer, Tumour Biol, 2015;36:4357–4365

[Adams_2017-9] {a et b} Adams CM, Kim AS, Mitra R, Choi JK, Gong JZ, Eischen CM, BCL-W has a fundamental role in B cell survival and lymphomagenesis, J Clin Invest, 2017;127:635-650

[Lee_2003-10] Lee HW, Lee SS, Lee SJ, Um HD, Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation, Cancer Res, 2003;63:1093–1100

[Wilson_2000-11] Wilson JW, Nostro MC, Balzi M, Faraoni P, Cianchi F, Becciolini A, Potten CS, Bcl-w expression in colorectal adenocarcinoma, Br J Cancer, 2000;82:178–185

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