MALAT1

MALAT1
Identifiants
Aliases	MALAT1
IDs externes	OMIM: 607924 GeneCards: MALAT1
Position du gène (Homme)
Chr.	Chromosome 11 humain
Fin	65,506,516 bp
Expression génétique
	Fortement exprimé dans
	Médullaire rénale; ; Ganglion de Gasser; ; cardia; ; corps calleux; ; pylore; ; vésicule séminale; ; tendon calcanéen; ; external globus pallidus; ; ganglion sensitif d’un nerf spinal; ; urètre;
	n/a
	Plus de données d'expression de référence
	n/a
Orthologues
	378938
	n/a
	ENSG00000251562
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
Voir/Editer Humain

Le MALAT1 (pour « metastasis associated lung adenocarcinoma transcript 1 ») est un long ARN non codant. Son gène est MALAT1 situé sur le chromosome 11 humain.

Rôle[modifier | modifier le code]

Il est exprimé particulièrement au niveau des poumons et du pancréas^[3].

Dans les cancers, il intervient dans la migration cellulaire et l'invasion des tissus sains^[4].

Au niveau vasculaire, il favorise le développement des cellules endothéliales^[5], des cellules musculaires lisses^[6] et de la vascularisation. Chez le diabétique, il intervient ainsi dans la néovascularisation^[7].

Au niveau moléculaire, il interagit avec la voie du P38-MAPK^[7]. Il inhibe l'expression du TNF-alpha et de l'interleukine 6 en empêchant la fixation du NF-κB sur l'ADN^[8]. Il favorise certains types d'épissage en jouant sur la phosphorylation de certains facteurs^[9]. Il cible également plusieurs micro-ARNs, dont le 506^[10], le 1^[11], le 200^[12], 145^[13] et le 206^[14], ce qui favorise la prolifération de certains cancers. De même, son interaction avec le miR-101b régule l'expression du RAC1, favorisant la fibrose hépatique^[15].

En médecine[modifier | modifier le code]

Il est exprimé par de nombreux cancers dont certains cancers bronchiques non à petites cellules et sa présence semble corrélée avec un risque plus important de métastases^[3].

Il serait protecteur quant à la formation de l'athérome, inhibant la prolifération des cellules hématopoïétiques^[16].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ ^{a et b} Ji P, Diederichs S, Wang W, Böing S et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer, Oncogene, 2003;22:8031–8041
↑ Dhamija S, Diederichs S, From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis, Int J Cancer, 2016;139:269–280
↑ Michalik KM, You X, Manavski Y et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth, Circ Res, 2014;114:1389–1397
↑ Brock M, Schuoler C, Leuenberger C et al. Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation, Exp Biol Med (Maywood), 2017;242:487–496
↑ ^{a et b} Liu JY, Yao J, Li XM et al. Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus, Cell Death Dis, 2014; 5:e1506
↑ Zhao G, Su Z, Song D, Mao Y, Mao X, The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB, FEBS Lett, 2016; 590:2884–2895
↑ Tripathi V, Ellis JD, Shen Z et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation, Mol Cell, 2010;39:925–938
↑ Lei R, Xue M, Zhang L, Lin Z, Long noncoding RNA MALAT1-regulated microRNA 506 modulates ovarian cancer growth by targeting iASPP, Onco Targets Ther, 2017;10:35–46
↑ Chou J, Wang B, Zheng T et al. MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42, Biochem Biophys Res Commun, 2016;472:262–269
↑ Xiao H, Tang K, Liu P et al. [=5357&path[]=17299 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma], Oncotarget, 2015;6:38005–38015
↑ Lu H, He Y, Lin L, Qi Z, Ma L, Li L, Su Y, Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145, Tumour Biol, 2016;37:1683–1691
↑ Wang SH, Zhang WJ, Wu XC et al. [=9347 Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206], Oncotarget, 2016;7:37857–37867
↑ Yu F, Lu Z, Cai J et al. MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis, Cell Cycle, 2015;14:3885–3896
↑ Cremer S, Michalik KM , Fischer A et al. Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation, Circulation, 2018;139:1320–1334

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl, May 2017

[2] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Ji_2003-3] {a et b} Ji P, Diederichs S, Wang W, Böing S et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer, Oncogene, 2003;22:8031–8041

[Dhamija_2016-4] Dhamija S, Diederichs S, From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis, Int J Cancer, 2016;139:269–280

[Michalik_2014-5] Michalik KM, You X, Manavski Y et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth, Circ Res, 2014;114:1389–1397

[Brock_2017-6] Brock M, Schuoler C, Leuenberger C et al. Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation, Exp Biol Med (Maywood), 2017;242:487–496

[Liu_2014-7] {a et b} Liu JY, Yao J, Li XM et al. Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus, Cell Death Dis, 2014; 5:e1506

[Zhao_2016-8] Zhao G, Su Z, Song D, Mao Y, Mao X, The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB, FEBS Lett, 2016; 590:2884–2895

[Tripathi_2010-9] Tripathi V, Ellis JD, Shen Z et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation, Mol Cell, 2010;39:925–938

[Lei_2017-10] Lei R, Xue M, Zhang L, Lin Z, Long noncoding RNA MALAT1-regulated microRNA 506 modulates ovarian cancer growth by targeting iASPP, Onco Targets Ther, 2017;10:35–46

[Chou_2016-11] Chou J, Wang B, Zheng T et al. MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42, Biochem Biophys Res Commun, 2016;472:262–269

[Xiao_2015-12] Xiao H, Tang K, Liu P et al. [=5357&path[]=17299 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma], Oncotarget, 2015;6:38005–38015

[Lu_2016-13] Lu H, He Y, Lin L, Qi Z, Ma L, Li L, Su Y, Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145, Tumour Biol, 2016;37:1683–1691

[Wang_2016-14] Wang SH, Zhang WJ, Wu XC et al. [=9347 Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206], Oncotarget, 2016;7:37857–37867

[Yu_2015-15] Yu F, Lu Z, Cai J et al. MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis, Cell Cycle, 2015;14:3885–3896

[Cremer_2018-16] Cremer S, Michalik KM , Fischer A et al. Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation, Circulation, 2018;139:1320–1334

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]