TRPM2

TRPM2
Identifiants
Aliases	TRPM2
IDs externes	OMIM: 603749 MGI: 1351901 HomoloGene: 20709 GeneCards: TRPM2
Position du gène (Homme)
Chr.	Chromosome 21 humain
Fin	44,443,081 bp
Position du gène (Souris)
Chr.	Chromosome 10 (souris)
Fin	77,970,563 bp
Expression génétique
	Fortement exprimé dans
	noyau caudé; ; noyau accumbens; ; monocyte; ; putamen; ; gyrus cingulaire; ; Brodmann area 9; ; cortex préfrontal; ; rate; ; hypothalamus; ; amygdale;
	Fortement exprimé dans
	rate; ; gyrus frontal supérieur; ; cerebellar cortex; ; sang; ; moelle osseuse; ; autopod region; ; thymus; ; proximal tubule; ; glande submandibulaire; ; pied;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	calcium channel activity; sodium channel activity; ion channel activity; cation channel activity; Calcium liaison ionique; calcium-release channel activity; activité hydrolase; ligand-gated calcium channel activity; liaison ion métal; ADP-ribose diphosphatase activity; mono-ADP-D-ribose binding;
Composant cellulaire	integral component of membrane; membrane; membrane plasmique; lysosome; lysosomal membrane; integral component of plasma membrane; membrane d'une vésicule cytoplasmique; vésicule cytoplasmique; specific granule membrane; prolongement cellulaire; péricaryon; tertiary granule membrane; ficolin-1-rich granule membrane;
Processus biologique	sodium ion transmembrane transport; sodium ion transport; cation transport; ion transport; response to oxidative stress; calcium ion transmembrane transport; calcium ion transport; ion transmembrane transport; transport transmembranaire; temperature homeostasis; dendritic cell chemotaxis; response to purine-containing compound; calcium-mediated signaling using intracellular calcium source; neutrophil degranulation; release of sequestered calcium ion into cytosol; regulation of filopodium assembly; cellular response to hydrogen peroxide; cellular response to calcium ion; cellular response to purine-containing compound; cellular response to temperature stimulus; zinc ion transmembrane transport; dendritic cell differentiation; calcium ion transmembrane import into cytosol; regulation of actin cytoskeleton reorganization; calcium ion import across plasma membrane; protein homotetramerization;
	Sources:Amigo / QuickGO
Orthologues
	7226
	28240
	ENSG00000142185
	ENSMUSG00000009292
	O94759
	Q91YD4
	NM_001001188; NM_003307; NM_001320350; NM_001320351; NM_001320352
	NM_138301
	NP_001307279; NP_001307280; NP_001307281; NP_003298
	NP_612174
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le TRPM2 (« Transient receptor potential cation channel, subfamily M, member 2 ») est une protéine, de type canal calcique dont le gène est TRPM2 situé sur le chromosome 21 humain.

Rôles[modifier | modifier le code]

Le canal est activé par l'adénosine diphosphoribose, le nicotinamide, le peroxyde d'hydrogène^[5] et le calcium intracellulaire^[6].

Il intervient dans la sécrétion d'insuline après charge glucidique ou injection d'incrétines^[7].

Il permet également la survenue d'une inflammation en augmentant la production de chimiokines^[8] et intervient dans l'apoptose^[9] par l'interaction de lui-même avec une version épissée de cette même protéine^[10].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000142185 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000009292 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Kolisek M, Beck A, Fleig A, Penner R, Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels, Mol Cell, 2005;18:61–69
↑ Du J, Xie J, Yue L, Intracellular calcium activates TRPM2 and its alternative spliced isoforms, Proc Natl Acad Sci U S A, 2009;106:7239–7244
↑ Uchida K, Dezaki K, Damdindorj B et al. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice, Diabetes, 2011;60:119–126
↑ Yamamoto S, Shimizu S, Kiyonaka S et al. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration, Nat Med, 2008;14:738–747
↑ McNulty S, Fonfria E, The role of TRPM channels in cell death, Pflugers Arch, 2005;451:235–242
↑ Hecquet CM, Zhang M, Mittal M et al. Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis, Circ Res, 2014;114:469–479

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000142185 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000009292 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[5] Kolisek M, Beck A, Fleig A, Penner R, Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels, Mol Cell, 2005;18:61–69

[6] Du J, Xie J, Yue L, Intracellular calcium activates TRPM2 and its alternative spliced isoforms, Proc Natl Acad Sci U S A, 2009;106:7239–7244

[7] Uchida K, Dezaki K, Damdindorj B et al. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice, Diabetes, 2011;60:119–126

[8] Yamamoto S, Shimizu S, Kiyonaka S et al. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration, Nat Med, 2008;14:738–747

[9] McNulty S, Fonfria E, The role of TRPM channels in cell death, Pflugers Arch, 2005;451:235–242

[10] Hecquet CM, Zhang M, Mittal M et al. Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis, Circ Res, 2014;114:469–479

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