KDM2B

KDM2B
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	4O64
Identifiants
Aliases	KDM2B
IDs externes	OMIM: 609078 MGI: 1354737 HomoloGene: 13069 GeneCards: KDM2B
Position du gène (Homme)
Chr.	Chromosome 12 humain
Fin	121,581,023 bp
Position du gène (Souris)
Chr.	Chromosome 5 (souris)
Fin	123,127,886 bp
Expression génétique
	Fortement exprimé dans
	éminence ganglionnaire; ; Vermis du cervelet; ; thymus; ; monocyte; ; muscle tibial antérieur; ; ganglion lymphatique; ; appendice iléo-cæcal; ; tibia; ; artère temporale superficielle; ; pancreatic ductal cell;
	Fortement exprimé dans
	éminence ganglionnaire; ; secondary oocyte; ; spermatocyte; ; morula; ; spermatide; ; mésencéphale; ; tube neural; ; lèvre; ; testicule; ; placenta;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	liaison ADN; liaison ARNr; zinc ion binding; dioxygenase activity; liaison ion métal; histone demethylase activity; liaison protéique; histone H3-methyl-lysine-36 demethylase activity; liaison ARN; activité d'oxydoréductase; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Composant cellulaire	nucléoplasme; nucléole; PcG protein complex; noyau; chromosome;
Processus biologique	negative regulation of neuron apoptotic process; midbrain-hindbrain boundary morphogenesis; regulation of transcription, DNA-templated; lateral ventricle development; histone H2A monoubiquitination; negative regulation of neural precursor cell proliferation; hindbrain development; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; third ventricle development; positive regulation of cell growth; embryonic camera-type eye morphogenesis; histone H3-K36 demethylation; spermatogenèse; forebrain development; positive regulation of stem cell population maintenance; initiation of neural tube closure; midbrain development; fourth ventricle development; organisation de la chromatine;
	Sources:Amigo / QuickGO
Orthologues
	84678
	30841
	ENSG00000089094
	ENSMUSG00000029475
	Q8NHM5
	Q6P1G2
	NM_001005366; NM_032590
NM_001003953; NM_001005866; NM_013910; NM_001378863; NM_001378864;
	NM_001378865
	NP_001005366; NP_115979
	NP_001003953; NP_038938; NP_001365792; NP_001365793; NP_001365794
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le KDM2B (pour lysine, donc l’abréviation est K, déméthylase 2B), ou NDY1, est une protéine dont le gène est KDM2B situé sur le chromosome 12 humain.

Rôles[modifier | modifier le code]

Il joue un rôle d'oncogène, facilitant la survenue de différents cancers, dont la leucémie aiguë myéloïde^[5] ou le cancer du pancréas^[6]. Il contribue à la prolifération des fibroblastes^[7] et favorise la formation et l'entretien de cellules soucbes pluripotentes^[8].

Il interagit avec le PRC1^[9] qui permet de réprimer l'expression de certains gènes. L'expression du KDM2B est régulé par le SOX2 et l'OCT4^[10].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000089094 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000029475 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ He J, Nguyen AT, Zhang Y, KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation maintenance of acute myeloid leukemia, Blood, 2011;117:3869–3880
↑ Tzatsos A, Paskaleva P, Ferrari F et al. KDM2B promotes pancreatic cancer via Polycomb-dependent -independent transcriptional programs, J Clin Invest, 2013;123:727–739.
↑ Tzatsos A, Paskaleva P, Lymperi S et al. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression senescence in primary cells, J Biol Chem, 2011;286:33061–33069.
↑ Liang G, He J, Zhang Y, Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming, Nat Cell Biol, 2012;14:457–466.
↑ Wu X, Johansen JV, Helin K, Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands regulates H2A ubiquitylation, Mol Cell, 2013;49:1134–1146.
↑ He J, Shen L, Wan M, Taranova O, Wu H, Zhang Y, Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes, Nat Cell Biol, 2013;15:373–384.

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000089094 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000029475 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[He_2011-5] He J, Nguyen AT, Zhang Y, KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation maintenance of acute myeloid leukemia, Blood, 2011;117:3869–3880

[Tzatsos_2013-6] Tzatsos A, Paskaleva P, Ferrari F et al. KDM2B promotes pancreatic cancer via Polycomb-dependent -independent transcriptional programs, J Clin Invest, 2013;123:727–739.

[Tzatsos_2011-7] Tzatsos A, Paskaleva P, Lymperi S et al. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression senescence in primary cells, J Biol Chem, 2011;286:33061–33069.

[Liang_2012-8] Liang G, He J, Zhang Y, Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming, Nat Cell Biol, 2012;14:457–466.

[Wu_2013-9] Wu X, Johansen JV, Helin K, Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands regulates H2A ubiquitylation, Mol Cell, 2013;49:1134–1146.

[He_2013-10] He J, Shen L, Wan M, Taranova O, Wu H, Zhang Y, Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes, Nat Cell Biol, 2013;15:373–384.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]