CXCR2

CXCR2
	Visualisation de la protéine Cristallisée CXCR2
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	4Q3H
Identifiants
Aliases	CXCR2
IDs externes	OMIM: 146928 MGI: 105303 HomoloGene: 10439 GeneCards: CXCR2
Position du gène (Homme)
Chr.	Chromosome 2 humain
Fin	218,137,251 bp
Position du gène (Souris)
Chr.	Chromosome 1 (souris)
Fin	74,200,405 bp
Expression génétique
	Fortement exprimé dans
	sang; ; ligament alvéolo-dentaire; ; granulocyte; ; os spongieux; ; epithelium of esophagus; ; monocyte; ; gonade; ; rate; ; cavité buccale; ; moelle osseuse;
	Fortement exprimé dans
	granulocyte; ; placenta; ; moelle osseuse; ; œsophage; ; embryon; ; rate; ; embryon; ; blastocyste; ; lèvre; ; poumon;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	C-X-C chemokine receptor activity; interleukin-8 binding; liaison protéique; interleukin-8 receptor activity; chemokine receptor activity; signal transducer activity; G protein-coupled receptor activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Composant cellulaire	integral component of membrane; membrane; mast cell granule; membrane plasmique; integral component of plasma membrane; intracellulaire; surface cellulaire; secretory granule membrane; external side of plasma membrane;
Processus biologique	neutrophil activation; internalisation de récepteur; dendritic cell chemotaxis; chimiotaxie; cellular defense response; phospholipase C-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; positive regulation of cell population proliferation; réponse inflammatoire; chemokine-mediated signaling pathway; neutrophil degranulation; G protein-coupled receptor signaling pathway; acute inflammatory response to antigenic stimulus; positive regulation of leukocyte chemotaxis; positive regulation of cytosolic calcium ion concentration; positive regulation of cardiac muscle cell apoptotic process; neutrophil chemotaxis; midbrain development; negative regulation of neutrophil apoptotic process; negative regulation of apoptotic process; positive regulation of vascular permeability; positive regulation of angiogenesis; metanephric tubule morphogenesis; positive regulation of neutrophil chemotaxis; transduction de signal; interleukin-8-mediated signaling pathway; réponse immunitaire; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologues
	3579
	12765
	ENSG00000180871
	ENSMUSG00000026180
	P25025
	P35343
	NM_001168298; NM_001557
	NM_009909
	NP_001161770; NP_001548
	NP_034039
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le CXCR2 est une protéine formant l'un des récepteurs à l'interleukine 8, de type récepteur couplé aux protéines G. Il est appelé également IL8RB. Son gène est le CXCR2 situé sur le chromosome 2 humain.

Rôles

Il intervient dans le recrutement des cellules inflammatoires dans le muscle cardiaque en cas d'ischémie myocardique^[5], dans la vascularisation synoviale en cas d'arthrite^[6], dans le système nerveux central^[7] ou dans les poumons^[8]. Il joue un rôle probable dans la genèse de l'hypertension artérielle^[9].

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000180871 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000026180 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Tarzami ST, Miao W, Mani K, Lopez L, Factor SM, Berman JW, Kitsis RN. Opposing effects mediated by the chemokine receptor CXCR2 on myocardial ischemia-reperfusion injury: recruitment of potentially damaging neutrophils and direct myocardial protection, Circulation, 2003;108:2387–2392
↑ Coelho FM, Pinho V, Amaral FA et al. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature, Arthritis Rheum, 2008;58:2329–2337
↑ Veenstra M, Ransohoff RM, Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?, J Neuroimmunol, 2012;246:1–9
↑ Konrad FM, Reutershan J. CXCR2 in acute lung injury, Mediators Inflamm, 2012;2012:740987
↑ Wang L, Zhao XC, Cui W et al. Genetic and pharmacologic inhibition of the chemokine receptor CXCR2 prevents experimental hypertension and vascular dysfunction, Circulation, 2016;134:1353–1368

Portail de la biologie cellulaire et moléculaire

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000180871 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000026180 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Tarzami_2003-5] Tarzami ST, Miao W, Mani K, Lopez L, Factor SM, Berman JW, Kitsis RN. Opposing effects mediated by the chemokine receptor CXCR2 on myocardial ischemia-reperfusion injury: recruitment of potentially damaging neutrophils and direct myocardial protection, Circulation, 2003;108:2387–2392

[Coelho_2008-6] Coelho FM, Pinho V, Amaral FA et al. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature, Arthritis Rheum, 2008;58:2329–2337

[Veenstra_2012-7] Veenstra M, Ransohoff RM, Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?, J Neuroimmunol, 2012;246:1–9

[Konrad_2012-8] Konrad FM, Reutershan J. CXCR2 in acute lung injury, Mediators Inflamm, 2012;2012:740987

[Wang_2016-9] Wang L, Zhao XC, Cui W et al. Genetic and pharmacologic inhibition of the chemokine receptor CXCR2 prevents experimental hypertension and vascular dysfunction, Circulation, 2016;134:1353–1368

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