JAM (protéine)

Les JAM (pour « junctional adhesion molécule ») sont une famille de protéines transmembranaires.

Membres

Rôles

Ce sont des protéines de type immunoglobuline^[1]. Elles se situent au niveau des jonctions serrées^[2], mais aussi à la surface des cellules sanguines^[1] et des cellules endothéliales et épithéliales^[3].

Notes et références

↑ ^{a et b} Mandell KJ, Parkos CA, The JAM family of proteins, Adv Drug Deliv Rev, 2005;57:857–867
↑ Martìn-Padura I, Lostaglio S, Schneemann M et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration, J Cell Biol, 1998;142:117–127
↑ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD, Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells, J Biol Chem, 2000;275:19139–19145

Portail de la biologie cellulaire et moléculaire

[Mandell_2005-1] {a et b} Mandell KJ, Parkos CA, The JAM family of proteins, Adv Drug Deliv Rev, 2005;57:857–867

[Martìn-Padura_1998-2] Martìn-Padura I, Lostaglio S, Schneemann M et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration, J Cell Biol, 1998;142:117–127

[Palmeri_2000-3] Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD, Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells, J Biol Chem, 2000;275:19139–19145

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