Utilisateur:MagaliN/Enterobacteria greA leader

The Enterobacteria_greA-leader is a putative attenuator element identified by bioinformatics^[1] within bacteria of the γ-proteobacterial Enterobacteriales order. It is located upstream of the rnk gene, encoding a transcription elongation factor, and presents a Rho-independent terminator at the 3' end. This RNA is presumed to operate as a non-coding leader, which regulatory mechanism remains to be elucidated. Interestingly, the short abortive form of the greA transcript may also play a role as an independent sRNA: Potrykus & al^[2] have shown that its overexpression leads to the repression of several genes. The motif might be related to other rnk-and greA-leaders, also described in RFAM, which are found within other bacterial phyla.

References[modifier | modifier le code]

↑ Naville M, Gautheret D, « The dark side of attenuation: large scale detection of functional 5' terminators in bacteria », Genome Biol. accepted,‎ 2010
↑ Potrykus K, Murphy H, Chen X, Epstein JA, Cashel M, « Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL », Nucleic Acids Res, vol. 38, n^o 5,‎ 2010, p. 1636-1651

Enterobacteria_greA-leader alignment [1]

[1] Naville M, Gautheret D, « The dark side of attenuation: large scale detection of functional 5' terminators in bacteria », Genome Biol. accepted,‎ 2010

[2] Potrykus K, Murphy H, Chen X, Epstein JA, Cashel M, « Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL », Nucleic Acids Res, vol. 38, n^o 5,‎ 2010, p. 1636-1651

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