GLI2

GLI2
Identifiants
Aliases	GLI2
IDs externes	OMIM: 165230 MGI: 95728 HomoloGene: 12725 GeneCards: GLI2
Position du gène (Homme)
Chr.	Chromosome 2 humain
Fin	120,992,653 bp
Position du gène (Souris)
Chr.	Chromosome 1 (souris)
Fin	118,981,349 bp
Expression génétique
	Fortement exprimé dans
	tibia; ; germinal epithelium; ; Veine saphène; ; stromal cell of endometrium; ; éminence ganglionnaire; ; cellule endothéliale; ; veine cave; ; pancreatic ductal cell; ; nerf sural; ; pleura viscéral;
	Fortement exprimé dans
	spermatogonie; ; derme; ; canal déférent; ; paroi abdominale; ; artère carotide externe; ; artère carotide interne; ; condyle; ; saccule; ; iris; ; corps ciliaire;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; liaison ion métal; RNA polymerase II cis-regulatory region sequence-specific DNA binding; zinc ion binding; liaison de chromatine; liaison protéique; Fixation d'acide nucléique; sequence-specific DNA binding; liaison ADN; transcription factor binding; promoter-specific chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	cytoplasme; cytosol; membrane; noyau; nuclear speck; Axonème; nucléoplasme; ciliary base; ciliary tip; nucléole; motile cilium; cil cellulaire; prolongement cellulaire;
Processus biologique	pattern specification process; skeletal system development; smoothened signaling pathway involved in ventral spinal cord interneuron specification; notochord regression; structure anatomique impliquée dans la morphogenèse; hindgut morphogenesis; spinal cord dorsal/ventral patterning; transcription by RNA polymerase II; mammary gland development; odontogenesis of dentin-containing tooth; prostatic bud formation; negative regulation of chondrocyte differentiation; cerebellar cortex morphogenesis; prolifération cellulaire; spinal cord ventral commissure morphogenesis; cellular response to virus; floor plate formation; regulation of transcription, DNA-templated; kidney development; développement des poumons; développement d'un tube; response to mechanical stimulus; embryonic digit morphogenesis; head development; développement d'un neurone; in utero embryonic development; transcription, DNA-templated; mammary gland duct morphogenesis; régulation positive de la transcription dépendante de l'ADN; morphogenesis of an epithelium; ventral midline development; développement du cœur; positive regulation of neuron differentiation; neural tube development; hedgehog; spinal cord motor neuron differentiation; epidermal cell differentiation; proximal/distal pattern formation; différenciation cellulaire; positive regulation of T cell differentiation in thymus; chondrocyte differentiation; développement d'une structure anatomique; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; cellular response to organic cyclic compound; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of DNA replication; developmental growth; osteoblast differentiation; osteoblast development; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; branching morphogenesis of an epithelial tube; embryonic digestive tract development; pituitary gland development; hindbrain development; ventral spinal cord development; Guidage axonal; développent d'un organisme multicellulaire; regulation of smoothened signaling pathway; smoothened signaling pathway involved in dorsal/ventral neural tube patterning; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; cochlea morphogenesis; positive regulation of cell population proliferation; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; prostate gland development;
	Sources:Amigo / QuickGO
Orthologues
	2736
	14633
	ENSG00000074047
	ENSMUSG00000048402
	P10070
	Q0VGT2
NM_005270; NM_030379; NM_030380; NM_030381; NM_001371271;
	NM_001374353; NM_001374354
	NM_001081125
	NP_005261; NP_001358200; NP_001361282; NP_001361283
	NP_001074594
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le GLI1 est un facteur de transcription à doigt de zinc, dont le gène est le GLI2 situé sur le chromosome 2 humain.

Rôles[modifier | modifier le code]

Il appartient à la famille des GLI, intervenant dans l'embryogenèse, en particulier du rachis^[5], et la cancérogenèse et régule la voie du Hedgehog^[6]. Le GLI2 est activée par le TGF bêta et par la voie du SMAD3^[7].

Cible thérapeutique[modifier | modifier le code]

Les dérivés arsenicaux (dont la darinaparsine) réduisent l'expression du GLI2^[8], et par ce biais, la voie du Hedgehog, ce qui pourrait expliquer leur action antitumorale^[9]. Par ce mécanisme, ces traitements pourraient également prévenir la formation d'une fibrose, en particulier au niveau rénal^[10].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000074047 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000048402 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Mo R, Freer AM, Zinyk DL et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development, 1997;124:113–123.
↑ Hui CC, Angers S, Gli proteins in development and disease, Annu Rev Cell Dev Biol, 2011;27:513–537
↑ Dennler S, André J, Alexaki I et al. Induction of sonic hedgehog mediators by transforming growth factor-β: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo, Cancer Res, 2007;67:6981–6986
↑ Kim J, Lee JJ, Kim J, Gardner D, Beachy PA, Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector, Proc Natl Acad Sci U S A, 2010;107:13432–13437
↑ Beauchamp EM, Ringer L, Bulut G et al. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway, J Clin Invest, 2011;121:148–160
↑ Kramann R, Fleig SV, Schneider RK et al. Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis, J Clin Invest, 2015;125:2935-2951

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000074047 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000048402 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Mo_1997-5] Mo R, Freer AM, Zinyk DL et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development, 1997;124:113–123.

[Hui_2011-6] Hui CC, Angers S, Gli proteins in development and disease, Annu Rev Cell Dev Biol, 2011;27:513–537

[Dennler_2007-7] Dennler S, André J, Alexaki I et al. Induction of sonic hedgehog mediators by transforming growth factor-β: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo, Cancer Res, 2007;67:6981–6986

[Kim_2010-8] Kim J, Lee JJ, Kim J, Gardner D, Beachy PA, Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector, Proc Natl Acad Sci U S A, 2010;107:13432–13437

[Beauchamp_2011-9] Beauchamp EM, Ringer L, Bulut G et al. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway, J Clin Invest, 2011;121:148–160

[Kramann_2015-10] Kramann R, Fleig SV, Schneider RK et al. Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis, J Clin Invest, 2015;125:2935-2951

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]